渗透膜｜仿生肠膜 Product presentation: PermeaPad® & PermeaPlain

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2021-06-20 13:35

1.PermeaPad

How?

Sandwich set-up with two cellulose-hydrate membranes and a dry phospholipid layer in between
In the hydrated form the phospholipids forms vesicles with a bilayer structure
Protection of the lipid → excellent stability

Why?

• A good dissolution does not necessarily give a good permeation and thus good bioavilability (BA)

• Permeability is a key- parameter that determines the oral BA

• Availability and reproduction of alternative membranes are limited

2. PermeaPlain

How?

• The PermeaPlain Barrier is a cellulose-hydrate membrane without lipid

Differences to PermeaPad®

Faster permeation rate with the PermeaPlain membrane
Only recommended for pH-

independent compounds
Not biomimetic

Why?

A good dissolution does not necessarily give a good permeation and thus good BA
Permeability is a key- parameter that determines the oral BA

3. Properties of PermeaPad® Barrier

Figure : Overview of the applications of the different cell- free permeation systems in (non)-oral drug delivery. [3]; modified.

4. PermeaPad® & PermeaPlain

1: Cover
2: Insert-plate with Barrier
3: Bottom plate

5. PermeaPad® Barrier

Measure the passive mass transfer/ permeability of drugs through a biomimetic barrier

• Robust
• Resistant
• Long shelf-life

Application:
Use it if you want to test with larger quantities and if you do not have many samples → Dissolution & Permeation

→The diffusion is direction independent

6.PermeaPad® Plate

The developed 96-well multiwell plate system enables a breakthrough in high-throughput permeability screening.

• Simple
• Fast
• Reproducible
• Comparable measurements

→ Generating a diffusion test setup → Ready to use

Application: Use it if you have small quantities and if you have many samples
→ High-throughput permeability screening of NCEs or pre formulation screening

Liquid handler

HPLC